Abstract
Dysbiosis of gut microbiota disrupts intestinal homeostasis and not only causes inflammatory bowel diseases but is also involved in other diseases. Intestinal IgA has been shown to shape the gut microbiota community. However, how secreted IgA regulates gut microbiota is not yet understood. We established hybridomas from intestinal lamina propria-derived IgA-secreting cells of wild-type mice, and identified the target bacterial epitope of intestinal IgA. Here, we describe one of the mechanisms by which intestinal IgA regulates gut microbiota.
