Abstract
A case of head injury with rhabdomyolysis during thiamylal therapy is reported. The total dose of thiamylal was 489mg/kg, which was higher than that in the usual barbiturate therapy. The blood concentration of thiamylal seemed to be more than 10mg/dl on the CPK max-day, and without plasma exchange, CPK and s-Mb were decreased within 24 hours after stoppage of the thiamylal treatment. This suggests that the cause of this rhabdomyolysis was not pressure necrosis, arterial occlusion nor infection, but thiamylal intoxication. The mechanism of this rhabdomyolysis seemed to involve an abnormality of cell membrane function induced by thiamylal intoxication.
