Abstract
Whereas mammographic density and adiposity are positively associated with postmenopausal breast cancer risk, they are inversely associated with one another. In order to evaluate the relationships of anthropometric adiposity factors, breast cancer risk factors, and serum glucose and lipid levels with mammographic density, we carried out a cross-sectional analysis of healthy postmenoposal women enrolled in the Ebina Health Service Center in 2011, comprising 153 with BI-RADS category I and II density (group LD) and 151 with BI-RADS category III and IV density (group HD). Unvariate analysis, showed that women in the LD group were significantly more obese, with higher levels of TG and lower levels of HDL-C, than those in the HD group (p<0.001, respectively). Multivariate analysis revealed that body weight gain and the level of HDL-C were independently associated with MD after taking into account the possible confounding effects of age and BMI (OR 0.47 95%CI 0.28-0.79 p=0.004, OR 0.50 95%CI 0.28-0.89 p=0.0018, respectively). We conclude that not only anthropometric factors but also body weight gain are important predictors of breast density.
