Studies on Coumarin-3-carboxylic Acid and its Derivatives as Rat Poison

I. Fundamental Investigations with Rat (Rattus norvegicus var. albinus) and Mouse (Mus musclus)

Abstract

According to the previous findings that coumarin-3-carboxylic acid and 6-coumarinylamine coumarin-3-carboxylate have a strong hypothermal action and toxic action to rats, a study was made in an effort to apply these compounds as rat poisons. These compounds and in addition, thallium coumarin-3-carboxylate have superior toxic effect on rat (Rattus norvegicus var. albinus) and mouse (Mus musclus), and have a little toxicity for domestic animals such as dogs and cats. Thus, there may be a possibility of application of these coumarins as rat poisons for practical use.