Novel molecular targeted and wide spectrum antitumor agents: Preparation and preclinical evaluation of IER5/Cdc25B targeted low-molecular-weight phospha sugar derivatives

Hiroko Hasegawa; Mitsuji Yamashita; Reiko Makita; Mayumi Yamaoka; Michio Fujie; Satoki Nakamura; Tatsuo Oshikawa; Junko Yamashita; Manabu Yamada; Mitsuru Kondo; Kazutaka Hirakawa; Mitsuo Toda; Yasuo Takehara; Kazunori Ohnishi; Haruhiko Sugimura; Sophie Laurent; Robert N. Muller

doi:10.56646/jjapcp.4.0_011301

14th International Conference on Global Research and Education, Inter-Academia 2015

Session ID : 011301

DOI https://doi.org/10.56646/jjapcp.4.0_011301

Conference information

Host: Shizuoka Univesity

Name : 14th International Conference on Global Research and Education, Inter-Academia 2015

Location : Hamamatsu, Japan

Date : September 28, 2015 - September 30, 2015

Biology and biomaterial

Novel molecular targeted and wide spectrum antitumor agents: Preparation and preclinical evaluation of IER5/Cdc25B targeted low-molecular-weight phospha sugar derivatives

Hiroko Hasegawa, Mitsuji Yamashita, Reiko Makita, Mayumi Yamaoka, Michio Fujie, Satoki Nakamura, Tatsuo Oshikawa, Junko Yamashita, Manabu Yamada, Mitsuru Kondo, Kazutaka Hirakawa, Mitsuo Toda, Yasuo Takehara, Kazunori Ohnishi, Haruhiko Sugimura, Sophie Laurent, Robert N. Muller

Author information

Hiroko Hasegawa
Graduate School of Science and Technology, Shizuoka University, Hamamatsu 432-8561, Japan
Mitsuji Yamashita
Graduate School of Science and Technology, Shizuoka University, Hamamatsu 432-8561, Japan
Reiko Makita
Graduate School of Science and Technology, Shizuoka University, Hamamatsu 432-8561, Japan
Mayumi Yamaoka
Graduate School of Science and Technology, Shizuoka University, Hamamatsu 432-8561, Japan
Michio Fujie
Faculty of Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan
Satoki Nakamura
Faculty of Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan
Tatsuo Oshikawa
Department of Chemistry and Biochemistry, Numazu National College of Technology, Numazu,Shizuoka 410-8501, Japan
Junko Yamashita
Graduate School of Science and Technology, Shizuoka University, Hamamatsu 432-8561, Japan
Manabu Yamada
Graduate School of Science and Technology, Shizuoka University, Hamamatsu 432-8561, Japan
Mitsuru Kondo
Graduate School of Science and Technology, Shizuoka University, Hamamatsu 432-8561, Japan
Kazutaka Hirakawa
Graduate School of Science and Technology, Shizuoka University, Hamamatsu 432-8561, Japan
Mitsuo Toda
Graduate School of Science and Technology, Shizuoka University, Hamamatsu 432-8561, Japan
Yasuo Takehara
Faculty of Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan
Kazunori Ohnishi
Faculty of Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan
Haruhiko Sugimura
Faculty of Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan
Sophie Laurent
Faculty of Medicine, University of Mons, Mons, Hainaut, Belgium
Robert N. Muller
Faculty of Medicine, University of Mons, Mons, Hainaut, Belgium

CONFERENCE PROCEEDINGS OPEN ACCESS

Details

Abstract

Novel broad spectrum low-molecular-weight antitumor agents of phospha sugar derivatives were investigated and developed. Branched deoxybromophospha sugars, such as DBMPP and TBMPP, which target IER5/Cdc25B and innovate in chemo-therapeutic treatments against various type of cancer cells. These successful preclinical in vitro and in vivo evaluations observed might be expected to afford clinically useful drugs and innovative medical treatments for various kinds of cancers.

Corresponding author

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