THE IMPACT OF PRE-INJURY ANTICOAGULANT AND ANTIPLATELET MEDICATION ON HEMOSTATIC INTERVENTIONS IN SEVERE TRAUMA PATIENTS WITHOUT BRAIN INJURY

Abstract

  〔Background〕The purpose of this study was to determine whether pre–injury use of anticoagulant and antiplatelet (antithrombotic) agents is related with hemostatic interventions. 〔Methods〕A retrospective review of 312 trauma patients without brain injury from J–OCTET database was performed. Patients were divided into pre–injury medication group and non–medication group. The impact of pre–injury antithrombotic medication on the composite outcome, defined as administration of fresh frozen plasma≧10 units and/or hemostatic treatments within 24h, was analyzed as primary outcome. 〔Results〕Pre–injury medication group was consisted with 20 patients (6.4%). Survival time was not different in two groups (P=0.361 in log–rank test). Logistic regression analysis using age, gender, injury severity score, and pre–injury antithrombotic medication as explanatory variables showed that pre–injury medication was one of the independent risk factors for the composite outcome [odds ratio ; 3.16, 95% confidential interval ; 1.08–9.10, P<0.05] . 〔Conclusions〕Pre–injury antithrombotic medication in severe trauma patients without brain injury may be associated with higher risk of hemostatic interventions.