2018 Volume 32 Issue 2 Pages 51-58
Pathology of organ damage after hemorrhagic shock by resuscitation with hypertonic saline or lactated Ringer's solution was examined. Neutrophil function was suppressed or augmented depending on the timing of administration of hypertonic saline. Cytokines of IL-6, IL-10, MCP-1 and TNF-α were elevated at 2h after hemorrhagic shock and resuscitation. Hypertonic saline reduced inflammatory cytokine production. Lung damage was observed at 24h after hemorrhagic shock and resuscitation. Hypertonic saline significantly reduced lung damage compared to lactated Ringer's solution. Also, early administration of hypertonic saline reduced lung damage compared with late administration. Apoptosis in the small intestine was observed at 2h and intestinal damage was observed at 6h after hemorrhagic shock and resuscitation. Hypertonic saline significantly reduced apoptosis and intestinal damage compared to lactated Ringer's solution. Effect of hypertonic saline on acute kidney injury was not seen. Since small volume of hypertonic saline administration restores blood pressure of hemorrhagic shock patients, administration of hypertonic saline may be useful for prehospital cases.
