Using Linkage Map of Mouse for Prediction of Gene Location in Animals

Abstract

The high-density linkage map of mouse has been constructed. This map contains quantitative trait loci (QTL) and major genes which are not mapped on other animals. In this study, a Bayesian model was developed to predict the chromosome number of unmapped genes in animals using comparative mapping data in contrast with mouse linkage map. The comparative mapping data of mouse-human, mouse-rat and mouse-cattle is collected from the Animal Genome Database. In order to examinethe accuracy of our method, we randomly divided the data into two subsets. The ratios of chromosomal translocation of mouse-human, mouse-rat and mouse-cattle were estimated by one of the subsets, and the chromosome numbers of mapped genes of human, rat and cattle were predicted for another subset.