Abstract
Many maximum contrast methods have been used to evaluate the dose-response relationship in clinical trials and in toxicological trials. However, the calculation method for p-value and power of such methods in practical form have not been proposed due to the complex property of integration in the multivariate t-distribution with singular correlation matrix. Addressing this issue, this paper presents SAS/IML programs for computing p-value, power and sample size necessary in the application of maximum contrast methods. It was confirmed that the speed of calculation in the proposed programs was far superior to the naive Monte-Carlo simulation keeping the precision as well.
