Abstract
To evaluate effects of impaired glucose tolerance on aortic stiffness, pulse wave velocity was measured in 1) subjects with impaired glucose tolerance (n=40) or 2) diabetes mellitus (n=58), or 3) in age-and sex-matched controls with normal glucose tolerance (n=40, 57 ± 2 yrs, 17men). After overnight fasting, pulse wave velocity between right brachial artery to bilateral ankle arteries (baPWV) was obtained from simultaneous recordings of pulse wave in four limbs (Form PWV/ABI, Colin AT company, Nagoya, Japan). 1. baPWV were controls (1339 ± 47 m/s) < impaired glucose tolerance (1562 ± 43) < diabetes mellitus (1763 ± 53) (p<0.001). 2. In stepwise multiple regression analysis, age and systolic blood pressure correlated to baPWV in controls (adjusted R2=0.690, p<0.001); age and systolic bool pressure and HOMA-IR (the homeostasis model insulin resistance index) in impaired glucose tolerance (R2=0.566, p<0.001); age, systolic blood pressure, HbAlc and plasma triglyceride in diabetics (R2=0.519, p<0.001). Values not included in the model were total cholesterol, triglyceride, body mass index, and HDL-cholesterol. Data suggested that baPWV could be useful to predict early atherosclerotic changes in subjects with impaired glucose tolerance, and predictors for baPWV could be influenced by glucose tolerance.
