Abstract
Diabetes mellitus (DM) is common in patients with heart failure (HF). However, the prognostic and pathogenic effects of DM on HF have not been clarified. The aim of this study was to evaluate the prognosis and pathogenesis of HF of DM and non-DM patients. From January 2002 to August 2004, 678 patients with HF were admitted to our hospital and they were divided into a DM group (n=128) and non-DM (NDM) group (n=550). The DM had their fasting blood sugar level (FBS≥126mg/dl) evaluated several times. No significant differences were found in age, gender, habit of smoking, hyperlipidemia, hypertension, ischemia heart disease (IHD), valvular heart disease, arrhythmia, medication, NYHA class or BNP. The DM group had a significantly higher body mass index than NDM.The incidences of re-admission were significant increased in DM than in NDM (44% vs 25%, p<0.01). Regarding the reasons for re-admission, uncontrolled hypertension and IHD were significantly higher in DM than in NDM.Concerning echocardiography, no significant differences were found in left ventricular (LV) ejection fraction or LV size. However, the E/A ratio was significantly lower (0.56±0.10 vs 0.78±0.11, P<0.05) and deceleration time was significant longer (262±llmsec vs 224±15msec, P<0.01) in DM than in NDM. These results suggest that DM leads to LV diastolic dysfunction and re-admission for HF and that DM is one of the important factors which mediates the pathogenesis and prognosis of HF.
