The effectiveness of patches containing Loxoprofen Sodium Hydrate (LX-P) in the conservative therapy of muscular back pain—Clinical results using the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ)

Abstract

Asami T, Yamanouchi N, Asami A, Tanaka H, Nogami N. The effectiveness of patches containing Loxoprofen Sodium Hydrate (LX-P) in the conservative therapy of muscular back pain - Clinical results using the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ). Jpn J Compr Rehabil Sci 2013; 4: 22-29.
Objectives: We investigated the analgesic effect, degree of patient satisfaction, and QOL improvement provided by patches containing loxoprofen sodium hydrate (LX-P) using a questionnaire based on the evaluation criteria of the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ).
Methods: In this study of 53 patients (18 men, 35 women) with muscular back pain, LX-P 100mg was applied once per day for four weeks. Patients provided subjective feedback by answering a questionnaire.
Results: After one week of LX-P application, Visual Analogue Scale (VAS) scores were significantly lower and in the fourth week over 50% of the patients who had switched from other NSAIDs reported improved satisfaction over the drug previously used. The JOABPEQ Severity of Illness Index (for all patients) was significantly higher after one week for pain- related disability and lower back functional disorder, and was significantly higher after two weeks for daily life disability. The rate of effectiveness of LX-P against pain-related disabilities in the fourth week was 62.2%.
Conclusion: LX-P showed satisfactory analgesic effect and QOL improvement. We believe it is effective for clinical practice.