Abstract
Case 1: A 36–year–old man admitted for lower right abdominal pain underwent appendectomy based on a diagnosis of appendicitis. The microscopy diagnosis was appendiceal adenocarcinoma in situ.
Case 2: An 81–year–old man with metastatic renal cell carcinoma treated using multikinase inhibitor and referred for fever and abdominal pain underwent appendectomy based on a diagnosis of appendicitis. A perforation was found in the appendiceal tip. Pathological examination showed adenocarcinoma in situ around the perforation. Because early vermiform appendix carcinoma is rare, we report these cases with a review of the literature.