Evaluation of Pre-operative Clinical Prognosticator in Gastric Cancer-from the Viewpoint of Neoadjuvant Chemotherapy (NAC)-

Abstract

Objective：The aim of this study is to evaluate the preoperative prognosticator for indication of neoadjuvant chemotherapy.
Methods：Nine preoperative prognostic factors were selected. Univarite and multivariate survival analysis were performed.
Results： In univariate analysis, sex lost prognostic significance. Multivariate analysis using Cox proportional hazard model identified that tumor size had the most effective factor for survival, followed by macroscopic type, cN(p＜0.001, respectively) and cT(p=0.002) in preoperative curative intent cases. However, in conclusive R0 cases (pathologic complete resection), cN and cT did not show prognostic independency, whereas tumor size and macroscopic appearance had predictive independency.
Conclusion：In selecting patients for NAC, cT, cN adding tumor size and macroscopic type also should be included.