Abstract
(Objectives) To investigate the efficacy of recombinant human thrombomodulin (rTM) in patients with disseminated intravascular coagulation (DIC) associated with colorectal perforation. (Subjects) Fourteen patients with colorectal perforation complicated by DIC who underwent surgery in our department from January 2011 to December 2011 and were treated with rTM were included as the subjects of this study. (Results) The mean age of the subjects was 77.6±16.6 years; the mean Sequential Organ Failure Assessment (SOFA) score was 7.71±2.63, the mean Simplified Acute Physiology ScoreⅡ(SAPSⅡ) score was 46.8±13.0, and there were 6 cases (42.8%) with septic shock at hospitalization. The mortality was 7.1%, and the mean duration of use of rTM was 6.46±1.27 days. All of the DIC score, SOFA score, fibrin degradation products (FDP), platelet (Plt), C-reactive protein (CRP), prothrombin time-international normalized ratio (PT-INR), Antithrombin Ⅲ (ATⅢ) improved significantly after the start of rTM administration as compared with the values prior to rTM treatment. There were no apparent adverse events associated with the administration of rTM. (Discussion) Our results suggested that rTM may be effective for the treatment of DIC associated with colorectal perforation.
