Abstract
We report two cases of women who were diagnosed with breast cancers after the onset of nephrotic syndrome (membranous nephropathy). Case 1 was a 46-year-old woman with proteinuria and hyperlipidemia. Invasive ductal carcinoma was found in her right breast during malignancy screening after she was diagnosed with membranous nephropathy by renal biopsy. We performed a breast conserving surgery and axillary lymph node dissection and then hormonal therapy was administered as adjuvant therapy. The patient has been disease-free for 9 years since and her nephrotic syndrome was resolved completely 2 years after the surgery. Case 2 was a 53-year-old woman with leg edema, proteinuria, hypoalbuminemia and hyperlipidemia. Scirrhous carcinoma was found in her right breast during malignancy screening after she was diagnosed with membranous nephropathy by renal biopsy. We performed a mastectomy and axillary lymph node dissection. Histological diagnosis was invasive ductal carcinoma with involvement of 14 axillary lymph nodes. Chemotherapy and hormonal therapy were administered as adjuvant therapy, but bone metastasis was discovered 1 year and 5 months after the surgery. She died 4 months later and nephritic syndrome did not resolved throughout.
