Abstract
The patient was a 56-year-old male with peritoneal disseminations of advanced gastric cancer. He underwent neoadjuvant chemotherapy with a combination of S-1 120mg/day (2 weeks administration and 2 weeks rest) and paclitaxel (PTX) 90mg/m2 (day 1 and 14, intraperitoneally:i.p.). After 2 courses of this regimen, CT revealed no evidence of ascites. Total gasterectomy and D1+lymph node dissection was performed. Cytology of ascites proved negative but peritoneal dissemination remained. The pathological stage was determined as T3 N0 H0 P1 CY0 M0, pStage Ⅳ. Twenty-one days after surgery, S-1+PTX i.p. chemotherapy was provided. We have continued this chemotherapy for seventy-three times. Grade I diarrhea, stomatitis and anorexia were confined throughout the all clinical course.
A condition of no progression has been achieved and maintained for more than five years. PTX i.p. and S-1 chemotherapy may well be one of the effective option for the treatments of gastric cancer with peritoneal disseminations.
