Abstract
Modified radical mastectomy were performed for the squamous cell carcinoma (SCC) of the right breast. At 10 months after surgery, anterior chest wall tumor, which was diagnosed as parasternal lymph nodes recurrence of SCC, was successfully treated by radiotherapy. Although first (Docetaxel and zoledronate), second (CDDP＋5-FU) and third (S-1) line chemotherapy were performed, she died from the cancer with metastases to bone, lung, lymph nodes and kidney 21 months after operation. During the postoperative clinical course, serum SCC antigen was markedly decreased after radiotherapy and S-1, whereas CEA level increased at all times. In addition, S-1 improved lung and part of lymph nodes metastasis. This case suggests that adenocarcinoma and SCC components in the SCC of the breast may show different sensitivity to any therapy and distinct behavior through the metastasis.
