Abstract
A 54-year-old female underwent resection of esophageal cancer. Because of the final diagnosis of Stage Ⅱesophageal cancer, 5-fluorouracil (5-FU) and cisplatin were chosen for adjuvant chemotherapy. After 2course of adjuvant chemotherapy, we found out a cervical lymph node reccurence. Treatment with 5-FU/cisplatin chemotherapy was restarted. On 4 course day 7, the patient presented with neurological disorders including anarthria and cerebellar ataxia. Brain MRI revealed leukoencephalopathy. After cessation of 5-FU and cisplatin, neurological symptoms diminished over 2 days. At the same time, the abnormal MRI findings are almost disappeared. Drug-induced leukoencephalopathy is known to be caused by various anti-neoplastic agents. 5-FU and cisplatin are key drugs of the several chemotherapy for solid cancer, so it is thought that we took the possibility of neurologic complications such as the leukoencephalopathy.
