A Case of Advanced Gastric Cancer with Gastric Outlet Obstruction Placed a Duodenal Stent Achieved Pathological Complete Response after Neoadjuvant Chemotherapy

Abstract

A subset of patients with advanced gastric cancer has the possibility of receiving R0 resection, although the potential of recurrence after surgery is high. Neoadjuvant chemotherapy with S-1 plus cisplatin may improve the prognosis of such patients. However, it is difficult to treat patients with advanced gastric cancer having gastric outlet obstruction as these patients exhibit difficulties with oral intake of S-1 and nutritional compromise. Therefore, radical gastrectomy tends to be chosen rather than neoadjuvant chemotherapy for these patients.

In this case, we could successfully administer neoadjuvant chemotherapy with S-1 plus cisplatin after performing a duodenal stent replacement. This may be the first case report describing a patient with gastric cancer who achieved complete pathological response with duodenal stent insertion, followed by neoadjuvant chemotherapy.

Duodenal stents may help multidisciplinary treatments for patients with advanced gastric cancer having gastric outlet obstruction.