2020 Volume 45 Issue 6 Pages 769-776
A 32-year-old female patient visited a neighborhood hospital complaining of hematemesis at 25 weeks of pregnancy. Careful examination revealed locally advanced gastric cancer with extensive lymph node metastasis, and she was referred to our hospital for treatment. Considering the stage of the pregnancy and the effects of chemotherapy on the fetus, delivery after S-1/DTX treatment was planned to provide for maximum fetal development in utero. After two courses, a baby girl weighing 2,374 g was delivered at 35 weeks of pregnancy. CT after 5 chemotherapy courses showed shrinkage of the primary tumor and lymph nodes. Thereafter, at 11 weeks after delivery, total gastrectomy (D2 + No.10) with splenectomy and Roux-en-Y reconstruction was performed. The histopathological diagnosis was ypT3N1M0, and the histological chemotherapy response was grade 2. She was started on postoperative adjuvant chemotherapy. Gastric cancer during pregnancy is extremely rare and is associated with a poor prognosis, and the effects of chemotherapy on the fetus and mother during pregnancy should be carefully considered.
We encountered a case in which chemotherapy was safely administered during pregnancy, and we present a report of the case, with a review of the literature.
