2022 Volume 47 Issue 4 Pages 525-533
A 60-year-old man was admitted to our hospital for treatment of a type 2 tumor detected on the lesser curvature at the gastric cardia, and biopsy revealed the diagnosis of poorly differentiated tubular adenocarcinoma. Abdominal CT revealed swelling of multiple lymph nodes in the No.1, 3a, and 7 stations, with a maximum diameter of the enlarged lymph nodes of 30 mm. Based on the findings of laparoscopy, the patient was diagnosed as having gastric cancer, T3N2M0, cStageⅢ, and was started on chemotherapy. After 3 courses of chemotherapy containing docetaxel+oxaliplatin+S-1 (DOS), both the primary tumor and the lymph nodes showed marked decrease in size; thereafter, total gastrectomy with lymph node dissection (D2+ No.16a2int+ No.16b1lat) was performed. Postoperative histopathology did not reveal any residual cancer cells in either the primary lesion or the lymph nodes; thus, the treatment effect of chemotherapy was classified as Grade 3. Thus, some gastric cancer patients may undergo curative resection even in the presence of extensive lymph node metastases when effective chemotherapy has been administered. Further discussions are needed about the optimal chemotherapeutic regimens in such cases. Herein，we report a case of advanced gastric cancer with pathological complete response after neoadjuvant chemotherapy with the DOS regimen.
