2024 Volume 49 Issue 5 Pages 435-440
A 31-year-old woman presented with masses in her left breast at 12 weeks of gestation. She had a past history of right breast cancer and underwent breast-conserving surgery with sentinel lymph node biopsy. Histological diagnosis confirmed pT2pN0cM0 pStage ⅡA triple-negative breast cancer. She received four courses of doxorubicin and cyclophosphamide (AC) followed by weekly doses of paclitaxel (wPTX) as adjuvant chemotherapy, as well as radiation therapy. The tumor was an invasive triple-negative ductal carcinoma, and the stage was cT2cN1cM0 cStage ⅡB. We performed total mastectomy with axillary dissection at 15 weeks of gestation, and the pathological diagnosis was determined to be pT2pN0cM0 pStage ⅡA. At 21 weeks of gestation, the patient received four courses of AC while being monitored by cardiologists and gynecologists. She delivered vaginally at 37 weeks and 3 days of gestation without any fetal abnormalities. Three weeks after delivery, she received wPTX. Perioperative chemotherapy, including administration of anthracycline, was successfully performed without any cardiac dysfunction. The patient received appropriate treatment through a multi-professional collaboration that included cardiologists and gynecologists.
