開心術中心虚血/再灌流障害に対する好中球の関与

郷良 秀典; 西田 真彦; 平田 健; 美甘 章仁; 池田 宜孝; 岡田 治彦; 浜野 公一; 善甫 宣哉; 江里 健輔

doi:10.4326/jjcvs.31.8

Role of Neutrophils in Ischemia/Reperfusion Injury during Heart Surgery

Hidenori Gohra, Masahiko Nishida, Ken Hirata, Akihito Mikamo, Yoshitaka Ikeda, Haruhiko Okada, Kimikazu Hamano, Nobuya Zempo, Kensuke Esato

Author information

Hidenori Gohra
First Department of Surgery, Yamaguchi University School of Medicine
Masahiko Nishida
First Department of Surgery, Yamaguchi University School of Medicine
Ken Hirata
First Department of Surgery, Yamaguchi University School of Medicine
Akihito Mikamo
First Department of Surgery, Yamaguchi University School of Medicine
Yoshitaka Ikeda
First Department of Surgery, Yamaguchi University School of Medicine
Haruhiko Okada
First Department of Surgery, Yamaguchi University School of Medicine
Kimikazu Hamano
First Department of Surgery, Yamaguchi University School of Medicine
Nobuya Zempo
First Department of Surgery, Yamaguchi University School of Medicine
Kensuke Esato
First Department of Surgery, Yamaguchi University School of Medicine

JOURNAL FREE ACCESS

2002 Volume 31 Issue 1 Pages 8-11

DOI https://doi.org/10.4326/jjcvs.31.8

Details

Abstract

To test the hypothesis that neutrophils play a role in ischemia/reperfusion injury during heart surgery, granulocyte elastase and myeloperoxidase release from coronary circulation were measured before and after aortic cross-clamping. The production of granulocyte elastase and myeloperoxidase across the coronary circulation elevated significantly after release of aortic cross-clamp. Furthermore, the level of granulocyte elastase and myeloperoxidase released from coronary circulation demonstrated positive correlation with the duration of the aortic cross-clamp. These data indicate that neutrophils play a major role in ischemia/reperfusion injury occurring during heart surgery.

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