Abstract
The moderating effect of indigestible dextrin on postprandial rise in blood glucose level after sucrose loading has been well demonstrated. In this study we conducted a continuous ingestion study in WBN/Kob rats, which is known a spontaneous type-2 diabetes model, in order to evaluate the preventive effects of indigestible dextrin on aggravation of both glucose and lipid metabolism caused by the high-sucrose diet. By ingesting the high-sucrose diet, glucose tolerance after sucrose loading was impaired, both fasting blood glucose and plasma total-cholesterol levels were increased, and fat accumulation was increased after four weeks in WBN/Kob rats and after eight weeks in Wistar rats, respectively. Despite the WBN/Kob rats kept on the high-sucrose diet, both the impairment of glucose tolerance and fat accumulation were prominently alleviated by continuous ingestion of indigestible dextrin. Contrary, no preventing effect of pectin and corn-fiber on deterioration of glucose metabolism was observed in the high-sucrose fed WBN/Kob rats.
