A Comparative Study of Barley Bran and Wheat Bran on Incidence of DMH-induced Colon Carcinoma in Rats .

Abstract

The effect of barley bran on incidence of colon carcinoma was investigated in comparison with wheat bran . A total of 80 rats of the Fischer 344 strain were divided into four groups: (1) saline-barley bran (2)1, 2-dimethylhydrazinebarley bran (3) saline-wheat bran and (4) 1, 2-dimethylhydrazine-wheat bran. The rats fed the normal diet were pre-treated by subcutaneous injection of 1, 2-dimethylhydrazine or physiological saline twice a week for four weeks. Then the rats were fed the high fat diet containing barley bran or wheat bran for 33 weeks. The incidence of colon carcinoma was almost the same between the barley bran (53.5% ) and wheat bran (50.0%) groups. Also, the rats with carcinoma had same numbers of the tumor per rat in the two groups. There was no relationship between the incidence of colon carcinoma and cecal pH or short chain fatty acid concentration.