JOURNAL OF JAPANESE ASSOCIATION FOR DIETARY FIBER RESEARCH
Online ISSN : 2186-5108
Print ISSN : 1343-1994
ISSN-L : 1343-1994
The Safety of High-dose Repeated Oral Ingestion of Difructose Anhydride III in Healthy Humans
Akiko TAMURATakuya SHIOMIYasuhide OKUHARAKohsuke HAYAMIZUNorihiro SHIGEMATSUHiroto KIKUCHIFusao TOMITAHiroshi HARA
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2003 Volume 7 Issue 2 Pages 89-96

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Abstract

We conducted a high-dose, repeated ingestion study of difructose anhydrideIII (DFAIII) in humans. All subjects ingested 3g of DFAIII 3 times (9 g) daily for 4 weeks. Blood and urine samples were collected at pre- (day 0), mid-(day 14), and post- (day 29) ingestion periods. Stool condition and defecation frequency, diet menu, and the incidents of gastrointestinal and other symptoms were recorded for 6 weeks with the ingestion period bracketed. Some blood parameters, especially blood osmolarity, varied between day 0 and day 14 or day 29; however, these changes were not serious. Incidences of some gastrointestinal symptoms tended to rise only in the early stage of the ingestion period, though increased defecation frequency and the incidence of diarrhea did not recover completely until the ingestion period was concluded. These results show that high-dose, repeated ingestion of DFAIII could produce transitory diarrhea and some gastrointestinal symptoms, but no serious adverse effects.

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© Japanese Association for Dietary Fiber Research
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