Suppressive Effect of Dietary Fiber on Elevation of Serum Uric Acid Concentration Induced by Dietary Adenosine and Adenosine-5'-Monophosphate in Rats

Takashi KOGUCHI; Hiromi KOGUCHI; Hisao NAKAJIMA; Saburo TANAKA; Yuji YAMAMOTO; Satoshi INNAMI; Akio MAEKAWA; Tadahiro TADOKORO

doi:10.11217/jjdf2004.8.83

Takashi KOGUCHI, Hiromi KOGUCHI, Hisao NAKAJIMA, Saburo TANAKA, Yuji YAMAMOTO, Satoshi INNAMI, Akio MAEKAWA, Tadahiro TADOKORO

Author information

Takashi KOGUCHI
Department of Applied Biology and Chemistry, Faculty of Applied Bioscience, Tokyo University of Agriculture
Hiromi KOGUCHI
Department of Applied Biology and Chemistry, Faculty of Applied Bioscience, Tokyo University of Agriculture
Nagatanien Corporation
Hisao NAKAJIMA
Department of Food and Nutrition, Junior College of Nihon University
Saburo TANAKA
Faculty of Education, Bunkyo University
Yuji YAMAMOTO
Department of Applied Biology and Chemistry, Faculty of Applied Bioscience, Tokyo University of Agriculture
Satoshi INNAMI
Department of Applied Biology and Chemistry, Faculty of Applied Bioscience, Tokyo University of Agriculture
Akio MAEKAWA
Department of Applied Biology and Chemistry, Faculty of Applied Bioscience, Tokyo University of Agriculture
Tadahiro TADOKORO
Department of Applied Biology and Chemistry, Faculty of Applied Bioscience, Tokyo University of Agriculture

Keywords: adenosine, adenosine-5'-monophosphate, dietary fiber, rats, serum uric acid concentration Abbreviations used: 5'-AMP, Adenosine 5'-monophosphate; DF, dietary fiber; 5'-IMP, inosine-5'-monophosphate; WHC, water-holding capacity

JOURNAL FREE ACCESS

2004 Volume 8 Issue 2 Pages 83-91

DOI https://doi.org/10.11217/jjdf2004.8.83

Details

Abstract

This study was performed to examine the effects of several kinds of dietary fiber (DF) with different physical properties on the elevation of serum uric acid concentration induced by dietary adenosine and adenosine-5'-monophosphate (5'-AMP). Male Wistar strain rats, 4 weeks old, were fed diets with purine compounds-free and adenosine or 5'-AMP (30 mmoll kg diet each) together with or without 50g1 kg diet of DF (cellulose, chitin, chitosan or xanthan gum) for 20 days. The concentrations of uric acid, allantoin and urea nitrogen in serum elevated by additions of purine compounds to the fiber-free diet were significantly suppressed by the test DF as compared with fiber-free. This phenomenon was remarkable in the xanthan gum group. The suppressive effect of chitin and chitosan on the elevation of serum uric acid concentration induced by 5'-AMP was stronger than that induced by adenosine. The present results reveal that the elevation of serum uric acid concentration induced by dietary adenosine and 5'-AMP can be suppressed by DF, and the suppressive effect of DF varied with the type of DF.

Corresponding author

Register with J-STAGE for free!