Abstract
The histological effects of solubility behaviour and shape on the soft tissue stability of hydroxyapatite granules for grafting four categories of hydroxyapatite granules into the abdominal hypoderm of rats were examined.Three kinds of granules were on the market and another was newly developed.The granule, which showed a large repose angle, an irregular surface shape, and lower solubility stabilized quickly and also showed smaller deformation of implant-connective tissue complex.The inflammation of the implanted area healed in four weeks after implantation, although the stabilization of the implant-connective tissue complex of the granule which showed high solubility behaviour was recovered after three months.The compact surface, open pores ranging from 50 to 200μm in diameter, and also multi-nucleated shape of the newly developed granule promoted the osteoconduction of the granule applied to the region where the bone and soft tissue co-exist.
