Abstract
4-MET in the 4-META resin system was determined by NMR spectroscopy. 4-META was easily hydrolyzed to 4-MET. To investigate the biological activity of 4-MET, we examined the interaction of 4-MET with phosphatidylcholine and phosphatidyl ethanolamine liposomes at various pHs using NMR spectroscopy. Chnages in the chemical shift of the liposomes induced by 4-MET were small at pH7.0, but very large at pH2.5, indicating that 4-MET interacts markedly with phospholipids at a low pH. Since dentin is a highly solid buffer, it was concluded that the effect of 4-MET to damage the pulp would be small at pH7.0.
