Abstract
Chitosan is polysaccharide which can be extracted from crustacea and absorbed in vivo. Sintered bovine bone and synthesized hydroxyapatite are considered biocompatible and osteoconductive substances. In this study, chitosan and these osteoconductive materials were composited. A chitosan film was formed by mixing its sol with apatite materials, followed by neutralizing a CaO solution or a sodium by polyphospate solution. The chitosan sol was prepared by mixing chitosan with Malic acid or Malonic acid. The effect of neutralization on these solutions was investigated.
The following results were obtained;
The pH of chitosan sol prepared with Malic acid with was higher than that of chitosan sol prepared Malonic acid.
The pH value of chitosan sol mixed with hydroxyapatite was higher than that of chitosan sol mixed with bovine bone.
The viscosity of chitosan mixed with Malonic acid was higher than that of chitosan mixed with Malic acid.
The hardness of chitosan film prepared with Malonic acid exhibited a higher value than that of chitosan film prepared with Malic acid.
No significant differences in hardness were found between chitosan film neutralized by CaO solution and that neutralized by sodium polyphosphate solution.
Tensile strength of chitosan film neutralized by a CaO solution was higher than that neutralized by a sodium polyphosphate solution.
The elongation of chitosan film neutralized by sodium polyphosphate solution had higher value than that neutralized by a CaO solution.
