Cytotoxicity of Dental Monomers : I.Comparison of Two Bis-GMA Materials with Different Purities and TEGDMA Monomer

Abstract

Bis-GMA is one of the important dimethacrylates for dental composite resins.Some impurities were often detected in Bis-GMA contained in composites.Cytotoxicities of two raw materials of Bis-GMA with different purities were determined by the cell recovery test using L-929 and HEp-2 cells to screen the effects of the impurities.The purities of tested Bis-GMAs were 96 and 64% by weight.64% Bis-GMA showed higher cytotoxicity than 96% Bis-GMA due to water-soluble impurities.Fortunately, it was assumed that Bis-GMA employed in available composites contained fewer impurities than 64% Bis-GMA.Although TEGDMA monomer showed relatively strong cytotoxicity, it enhanced polymerization conversion of self-and photo-curable composite matrices.