Abstract
Seven metallic and three polymeric prosthetic materials were examined for cytotoxicity by the cell recovery rate using a saliva/tissue combination as an in vitro model. Titanium was not cytotoxic regardless of the addition of the artificial saliva. A cobalt-chromium alloy, silver-palladium alloy, silver-tin alloy, heat-curing resin and self-curing resins showed only slight cytotoxicity. A silver-indium alloy and nickel-chromium alloy had a moderate effect, and copper had a marked effect. There was a significant difference in some findings after artificial saliva addition, although some samples were not affected. The present findings suggest the usefulness of the saliva/tissue combination model for cytotoxicity testing of dental materials.
