Abstract
The mutagenicity of Bis GMA and Tri EDMA was tested by the Salmonella reversion assay. The mutagenic activity of the test compounds was determined using Salmonella typhimurium TA1535, TA1537, TA98 and TA100. Bis GMA and Tri EDMA did not show any mutagenic potential in the absence of S-9mix in any of the strains tested. Bis GMA preincubated with S-9mix showed a 2-fold increase in the number of revertants compared to the solvent treatedcontrol value in TA1537 and 1.5-fold increase in TA98. Tri EDMA preincubated with S-9mix showed a concentration related increase in the number of revertants above the spontaneous mutation rate that reached 1.7 times in TA1537 and 1.6 times in TA98. These results indicated that Bis GMA is mutagenic and Tri EDMA is possibly mutagenic only in the presence of the metabolic activation system.
