Abstract
To clarify the influence of dental metallic salts on biologic membranes, we investigated the phase transition properties (transition temperature, T; enthalpy, ΔH; entropy, ΔS; ΔT1/2; H/HHW value) of L-α-dipalmitoylphosphatidylcholine-cholesterol (DPPC-CS) liposomes induced by AgNO3, Ag(NH3) F, NaF, NaOCl, KI, CaCl2, FeCl3, ZnCl2, ZnI2, etc.using differential scanning calorimetry (DSC). Monovalent ions(Ag+, Na+, K+, F-, NO3-) had a small effect on the DSC properties of DPPC-CS liposomes, while divalent ions (Zn2+) due to ZnCl2 and ZnI2 had a large effect. The chloride salt of Ca2+ had a small effect on the lipid DSC properties. The chloride salt of Fe3+ had the largest effect on the DSC properties. We also studied the DSC properties of unsaturated phospholipid liposomes (L-α-phosphatidylcholine β-stearoyl-γ-oleoyl; PCSO) induced by I2, I- and OCl-. Such polarizable anions and iodide strongly affected the DSC properties, probably due to the halogenation of double bone in the acyl chains of PCSO.
