Abstract
For the development of a new delivery system for bone morphogenetic protein (BMP), BMP was bound to β-tricalcium phosphate (β-TCP). Powder β-TCP was synthesized from calcium hydrogenphosphate and calcium carbonate by the dry process method to make the best use of the advantages of the BMP, which show good bone inductive activity on the surface and enhancement of new tissue by reducing the area that the implant material occupies, The β-TCP + BMP complex and β-TCP for the controls only were implanted in the muscle pouches of mice. Three weeks later new bone formation was observed on the exterior surface of β-TCP + BMP complex but not of β-TCP controls. The bone inductive activity of the β-TCP + BMP complex is better than the BMP alone.The histological relation between the original tissue and the newly induced bone formation was normal and that of new bone and β-TCP was also good. Consequently, the β-TCP + BMP complex has good histocompatibility when implanted.
