Abstract
The purpose of this study is to elucidate the efficacy of chewing gum containing ginger, vitamin B6 and caffeine with the basic taste of sweet peppermint for prevention of motion sickness. Subjects were 12 men and 12 women (age 23.2±SD 2.4 years) who were likely to get motion sickness. Audio-visual stimulus experiment was conducted to induce motion sickness symptoms. Five intensities of stimuli were loaded at the order of weak to heavy. Subject put on a face-mounted display device to gaze at driving simulation images. After 30 minute rest, subject received 8min stimulus at each level and then answered two kinds of questionnaires about the subjective symptoms. Subject took a couple of capsules containing (1) starch, or (2) starch, ginger 250mg, caffeine 50mg, vitamin B6 10mg, or (3) test elements at two times of (2), 30min before first stimulus, otherwise chewed at a gum containing (4) peppermint, or (5) peppermint, ginger 27.8mg, caffeine 5.6mg, vitamin B6 1.1 mg, or (6) test element of two times of (5), 30min before the first stimulus and changed the gum for another every 10min. As the result, a chewing gum containing ginger 27.8mg, caffeine 5.6mg, vitamin B6 1.1mg reduced nausea or vomiting of motion sickness symptoms most effectively.
