4-META/MMA-TBB Resin and Pulpal Response

Abstract

　Interaction between 4-META/MMA-TBB resin and dental pulp was investigated in vivo and in vitro. ① A cavity was prepared and the pulp was exposed in the occlusal surface of the tooth and filled with 4-META/MMA-TBB resin. Newly formed dentin was recognized just below the agent. During the healing stage, no inflammatory cell was observed but macrophages were detected close to the newly formed dentin, where tunnnel defects were appeared. ② 4-META/MMA-TBB resin was applied on the surface of pulp and 0.5% agar in vitro to investigate the surface structure on the resin after polymerization. When polymerization occured on the pulp, the surface of the resin revealed rods in shape. On the other hand, abundant cavities were found at the resin surface on the 0.5% agar.

　Taken all together, the surface structure of polymerized 4-META/MMA-TBB may cause macrophage migration around the interface between pulp and resin.