A Case with Oliguria and Edema During the Treatment with Clobazam

Abstract

We reported a case with oliguria and edema induced by clobazam (CLB). He received the treatment with valproic acid and phenytoin to improve an intractable generalized epilepsy with a cerebral palsy and a severe mental retardation. At 38 years of age, he started to have an additional treatment with CLB (10mg/day). His convulsions successively disappeared, however, one month later, oliguria and edema were manifested in his lower extremities. One week after discontinuation of CLB, oliguria and edema disappeared. Six month later, because his convulsions were frequently observed, CLB was re-administrated in a dose of 2mg/day and its dose was gradually increased. At the dose of 7.5mg/day his convulsions significantly diminished but edema was manifested again. Two weeks after discontinuation of CLB, his edema disappeared again. These observations suggested the possibility that the treatment with CLB may induce oliguria and edema.