Effectiveness of Midazolam in the Treatment of Status Epilepticus in Children

Abstract

Status epilepticus in children is a medical emergency that requires prompt intervention. Diazepam is most commonly administered initially, whereas phenytoin is the anticonvulsant most used subsequently, in Japan. Intravenous diazepam is often associated with respiratory depression and hypotension and duration of its anticonvulsive effect is very brief. During intravenous infusion of phenytoin, cardiopulmonary depression can occur as well as venous complications and appearance of its anticonvulsive action is slow. Midazolam has many clinical and pharmacological advantages compared with other antiepileptic agents. It acts more rapidly and it is safer and more effective. Midazolam should be considered as an initial treatment for status epilepticus in children.