Abstract
At present, no drugs cure epilepsy itself. All conventional antiepileptic drugs (AEDs) are effective as an anti-ictogenic, but not anti-epileptogeneses. It is important to differentiate the notions between the genesis of epileptic seizures and epileptogenesis. Paradigm shift is necessary to continuing the development novel AEDs that inhibit epileptogenesis. Differentiation epileptogenesis from the genesis of epileptic seizures is a most important theme.
This article reviewed history of AEDs, limitation of existing AEDs, and status of epilepsy researches in experimental animals and clinical studies. Furthermore, our latest findings in anti-epileptogenic experiment using spontaneously epileptic rats were demonstrated. At last, future direction of epilptogenic research was discussed.
