2016 Volume 33 Issue 3 Pages 663-671
Since 2001, Japan participated in the European Registry of Antiepileptic Drugs and Pregnancy (EURAP), a prospective observational study launched in Europe in 1999 by a consortium of independent research groups, and later extended to several other nations worldwide, with an aim to collect data on the risk of antiepileptic drugs (AED) during pregnancy. We report here the current data of the Japanese registry to EURAP. Two hundred and eighty-four pregnancies were enrolled. Generalized epilepsy in the mother accounted for 29.6% and partial epilepsy 64.8%. Folic acid was taken in 81.1%. Exposed to AED monotherapy was 65.2% and polytherapy 34.4%. CBZ (34.5%), VPA (33.3%), PHT (18.9%), PB (18.9%), LTG (11.6%), CZP (8.4%), ZNS (6.0%), CLB (5.2%) and LEV (4.8%) were the drugs mainly prescribed. There were 4.0% incidence of spontaneous abortions, 2.4% incidence of induced abortions and 3.7% incidence of major foetal malformations. The Japanese registry to EURAP will continue to collect data and welcome new referrals.
