Abstract
Recent investigations provided us information of the existence of transfer and interference phenomena in the limblic system, especially amygdaloid kindled rats.
The present study, however, designed as an investigation in order to know whether these phenomenon in the neocortical kindling are similar in the limbic cortex or not.
Biopolar stimulating and recording electrodes were implanted, bilaterally, into the anterior frontal cortex, and methods of experiments for the development of kindling were adopted and employed as similar as possible to those for amygdaloid kindling.
As results, positive transfer was observed in one group, and negative transfer, or inhibitory event at the contralateral homologenous cortex, was observed in the other group. When retest of primary site kindling was done, it was further discovered that post-transfer interference was observed in the former group, and was not observed in the latter group.
It seemed to be suggested that frontal cortical kindled epileptogenesis might involve the development of activity in inhibitory system, whereas in excitatory system, too.
Therefore, the authors have concluded that neocortical kindling will differ from limbic kindling in their transfer.
