Abstract
The effecs of alcohol intake on epileptic seizures still remained unclear. Here we report the effects of alcohol on the kindled seizures from amygdaloid complex which are established as a model of secondarily generalized seizures. Alcohol (0.5-2g/kg/day i. p. for 8 days) dosage-dependently depressed the seizure stages (classified by Racine) and shortened the duration of the afterdischarge of the kindled rats. A low dosage of alcohol (0.25g/kg/day i. p.), however, elevated the final electrical threshold (FET). After the pretreatment for 8 days by a high dosage (2g/kg/day/i. p.), FET was increased only the first day. These effects of alcohol on the kindling may be due to alcohol function depressing the GABA actions at the focal site.
