1993 Volume 11 Issue 1 Pages 1-8
The c-fosmRNA expression of brain by means of Northern blot analysis after seizures induced by tossed-up stimulation of seizure-susceptible El [s] mice showed a peak 30 min, still remaining higher level of induction at 1 h and an attainment baseline by 2h. The mRNA expression by bemegride-induced seizures of El [s] and seizure-naive El [ns] mice was significantly elevated at 30 min and had rapidly reached baseline. Bemegride-induced c-fosmRNA expression of ddY mice attained a peak at 15 min and sharply declined thereafter. The particular prolongation of c-fosinduction observed in seizures of El mice seems to associate with abnormal plasticity by recurrent seizures. In Slot blot analysis, the induction of c-fosmRNA expression after seizures were gradually declined following order of tossed-up stimulated seizures of El [s], and bemegrideinduced seizures of El [s], El [ns] and ddY mice, suggesting that the different expression supposedely reflecting genetic seizure-susceptibility.
