Effects of Indeloxazine Hydrochloride on Amygdala Kindling Seizure in Rats

Comparison of Anticonvulsant Effects Among Indeloxazine Hydrochloride, Phenytoin, Diazepam and Imipramine

Abstract

The anticonvulsant effect of indeloxazine was investigated on the kindled seizure from the amygdaloid seizure, an assumed model of secondarily generalized seizures in human. Indeloxazine (0.25-10mg/kg i.p.) dose-dependently depressed the kindled seizure and shortened the evoked amygdaloid afterdischarge. A high dose of indeloxazine (40mg/kg i. p.), however, induced generalized seizures without electrical stimulations. Comparison of the effects of indeloxazine to those of phenytoin, diazepam and imipramine on the kindled seizures revealed that anticonvulsant actions of indeloxazine are similar to those of imipramine, but not to those of phenytoin and diazepam. This result suggests that indeloxazine may exert its action through the monoaminergic system in the brain.