The Japanese Journal of Genetics
Online ISSN : 1880-5787
Print ISSN : 0021-504X
ISSN-L : 0021-504X
ARTICLES
Spontaneous mutation rates in null and band-morph mutations of enzyme loci in Drosophila melanogaster
Ko HARADAShin-ichi KUSAKABETsuneyuki YAMAZAKITerumi MUKAI
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1993 Volume 68 Issue 6 Pages 605-616

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Abstract

Spontaneous mutations were accumulated for a total of 1,678,388 allelegenerations in several hundred replicate second chromosome lines. These lines were composed of a Cy chromosome and one of three different lethal bearing chromosomes from natural populations. Electrophoretic mobility and / or activity change was screened for seven enzyme loci. Forty-four null mutations were detected, but no band-morph mutations were observed. There is significant variation in null mutation rate among enzyme loci and among lethal chromosomes. This may be attributable to differences in the distribution of transposable elements among the lines. The band-morph mutation rate is pooled with previous results and becomes 7.48 × 10-7 with a 95% confidence limit of 2.04 × 10-7 to 1.91 × 10-6 per locus per generation. Similarly, the pooled null mutation rate becomes 1.30 × 10 -5 with 95% confidence limit of 1.15 × 10 -5 to 1.52 × 10-5 per locus per generation.

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© 1993 by The Genetics Society of Japan
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