Chromosomal localization of human, rat, and mouse protein phosphatase type 1β catalytic subunit genes (PPP1CB) by fluorescence in situ hybridization

Abstract

Using fluorescent in situ hybridization (FISH) method, gene encoding the catalytic subunit of protein phosphatase type 1β (PPP1CB) in human and its corresponding gene in rat (PP1δ) and mouse (dis2m2) were mapped to human 2p23, rat 6q21-q23, and mouse 12D, respectively. These results indicate that PPP1CB is a member of conserved syntenic group. It is shown that the genes encoding catalytic subunit of protein phosphatase type 1 family (PP1α, PP1β, and PP1γ in human and those corresponding genes in rat and mouse), in spite of their high identity, are located to different chromosomes in these three species.