2019 Volume 31 Issue 4 Pages 404-413
Most general hospitals treat patients with secondary mania and bipolar disorder with various complications. Therefore, clinicians must be aware of the adverse effects and drug-drug interactions. Secondary mania is often observed in elderly patients and usually occurs within 12 months after a head injury. Lithium needs to be administered cautiously in patients with heart failure and renal disorders, and combination therapy with diuretic and anti-inflammatory drugs requires close monitoring. Carbamazepine possesses anticholinergic properties and induces drug metabolizing enzymes. Valproic acid inhibits various drug metabolizing enzymes, and its use is unsafe during pregnancy. Lamotrigine needs to be administered cautiously in combination with inducers and inhibitors of uridine diphosphate glucuronosyltransferase.
