Abstract
We report a long-term survival case of alpha-fetoprotein (AFP) producing esophageal carcinoma after radical resection. A 49-year-old man admitted with dysphagia was found to have advanced carcinoma of the esophagogastric junction. Barrett's epithelium was found around tumor. Preoperative serum AFP was 89.8 ng/ml, necessitating lower esophagectomy and total gastrectomy. Histopathological studies showed moderately differentiated adenocarcinoma with lymph node metastasis. Tumor cells had clear cytoplasm and immunohistochemical staining for AFP was positive. Serum AFP concentration decreased and the man is alive without recurrence eight years after surgery. Since the operative curability is a factor associated with the survival of patients with AFP producing carcinoma, it is necessary to carry out an adequate operation.
